Regulation of gamma-delta T cell differentiation

Across TCGA patient cohorts, RNA activity of the Regulation of gamma-delta T cell differentiation pathway is significantly associated with the protein abundance of multiple proteins, with the UCEC cohort showing a particularly strong set of associations.

The most reproducible pathway-associated proteins across cancer lineages are PALD1, ANXA6, and DAB2, each associated with the pathway in up to 7 cancer types. Since the analysis shows associations rather than directional relationships, both pathway-to-partner and partner-to-pathway views are reported.

Each partner is linked to its corresponding Q-omics profile. The scatter plot shows the strongest association, Regulation of gamma-delta T cell differentiation activity versus PALD1 in UCEC (Pearson r = 0.38).

Pathway-associated proteins by consensus

Ranked by combined sampling and lineage consensus. X-score (pathway→partner) and Y-score (partner→pathway) are standardized regression coefficients; both directions are reported because the association is undirected. The reported p-values are derived from the association test.

Lineage	Partner protein	X-score	Y-score	p(X)	p(Y)	Sampling consensus	Lineage consensus
UCEC	PALD1 →	+0.369	+0.097	.001	<.001	3	7
COAD	ANXA6 →	+0.334	+0.049	.003	<.001	3	7
GBM	DAB2 →	+0.480	+0.061	.003	.007	3	7
OV	DOCK2 →	+0.595	+0.079	<.001	<.001	3	7
OV	HCLS1 →	+0.558	+0.065	.004	.001	3	7
OV	IL16 →	+0.595	+0.086	<.001	<.001	3	7

Each partner links to its Q-omics profile. Showing the 6 strongest associations by consensus.

GO:0045586 vs PALD1 — UCEC

Explore this scatter interactively →