Regulation of gamma-delta T cell differentiation

Across TCGA patient cohorts, RNA activity of the Regulation of gamma-delta T cell differentiation pathway is significantly associated with the RNA expression of multiple genes, with the CCRCC cohort showing a particularly strong set of associations.

The most reproducible pathway-associated genes across cancer lineages are CXCR2P1, MAP4K1, and TMEM106A, each associated with the pathway in up to 4 cancer types. Since the analysis shows associations rather than directional relationships, both pathway-to-partner and partner-to-pathway views are reported.

Each partner is linked to its corresponding Q-omics profile. The scatter plot shows the strongest association, Regulation of gamma-delta T cell differentiation activity versus CXCR2P1 in CCRCC (Pearson r = 0.10).

Pathway-associated genes by consensus

Ranked by combined sampling and lineage consensus. X-score (pathway→partner) and Y-score (partner→pathway) are standardized regression coefficients; both directions are reported because the association is undirected. The reported p-values are derived from the association test.

Lineage	Partner gene	X-score	Y-score	p(X)	p(Y)	Sampling consensus	Lineage consensus
CCRCC	CXCR2P1 →	+1.031	+0.610	.002	.004	3	4
HNSC	MAP4K1 →	+0.563	+0.507	.002	.004	2	4
GBM	TMEM106A →	+0.428	+0.387	<.001	.007	3	3
GBM	ZDHHC4P1 →	+0.667	+0.560	.008	.002	3	3
GBM	SIGLEC1 →	+1.251	+0.688	<.001	<.001	3	3
LSCC	WIPF1 →	+0.371	+0.585	<.001	<.001	3	3

Each partner links to its Q-omics profile. Showing the 6 strongest associations by consensus.

GO:0045586 vs CXCR2P1 — CCRCC

Explore this scatter interactively →