Regulation of gamma-delta T cell differentiation

Across TCGA patient cohorts, RNA activity of the Regulation of gamma-delta T cell differentiation pathway is significantly associated with the protein abundance of multiple proteins, with the UCEC cohort showing a particularly strong set of associations.

The most reproducible pathway-associated proteins across cancer lineages are ZC3HC1_S335, SYK, and TESK2_S460, each associated with the pathway in up to 3 cancer types. Since the analysis shows associations rather than directional relationships, both pathway-to-partner and partner-to-pathway views are reported.

Each partner is linked to its corresponding Q-omics profile. The scatter plot shows the strongest association, Regulation of gamma-delta T cell differentiation activity versus ZC3HC1_S335 in UCEC (Pearson r = 0.26).

Pathway-associated proteins by consensus

Ranked by combined sampling and lineage consensus. X-score (pathway→partner) and Y-score (partner→pathway) are standardized regression coefficients; both directions are reported because the association is undirected. The reported p-values are derived from the association test.

Lineage	Partner protein	X-score	Y-score	p(X)	p(Y)	Sampling consensus	Lineage consensus
UCEC	ZC3HC1_S335 →	+0.575	+0.634	<.001	<.001	3	3
COAD	SYK →	+0.314	+1.077	<.001	<.001	3	2
BRCA	TESK2_S460 →	+1.086	+1.288	<.001	<.001	3	2
UCEC	TNS1_S1269 →	+1.769	+0.730	<.001	<.001	3	2
BRCA	CTNND1_T310 →	-1.022	-0.581	<.001	.001	3	2
LSCC	HES1_S12 →	-0.703	-1.006	<.001	<.001	3	2

Each partner links to its Q-omics profile. Showing the 6 strongest associations by consensus.

GO:0045586 vs ZC3HC1_S335 — UCEC

Explore this scatter interactively →