Regulation of gamma-delta T cell differentiation

Across TCGA cell cohorts, RNA activity of the Regulation of gamma-delta T cell differentiation pathway is significantly associated with the drug response of multiple features, with the BLOOD_Leukemia cohort showing a particularly strong set of associations.

The most reproducible pathway-associated features across cancer lineages are Vinblastine, Docetaxel, and Olaparib, each associated with the pathway in up to 1 cancer types. Since the analysis shows associations rather than directional relationships, both pathway-to-partner and partner-to-pathway views are reported.

Each partner is linked to its corresponding Q-omics profile. The box plot shows the strongest association, Vinblastine grouped by Regulation of gamma-delta T cell differentiation-low versus -high activity in BLOOD_Leukemia.

Pathway-associated features by consensus

Ranked by combined sampling and lineage consensus. X-score (pathway→partner) and Y-score (partner→pathway) are standardized regression coefficients; both directions are reported because the association is undirected. The reported p-values are derived from the association test.

Lineage	Partner feature	X-score	Y-score	p(X)	p(Y)	Sampling consensus	Lineage consensus
BLOOD_Leukemia	Vinblastine →	-0.437	-1.527	.033	<.001	3	1
BLOOD_Leukemia	Docetaxel →	-0.296	-1.116	.006	.004	3	1
BLOOD_Leukemia	Olaparib →	-0.652	-1.417	.002	.015	3	1
BLOOD_Leukemia	PLX-4720 →	-0.469	-1.166	.012	.002	3	1
BLOOD_Leukemia	Mirin →	-0.371	-0.893	.011	.048	3	1
BLOOD_Leukemia	MK-2206 →	-0.802	-1.277	.026	.008	3	1

Each partner links to its Q-omics profile. Showing the 6 strongest associations by consensus.

Vinblastine by Regulation of gamma-delta T cell differentiation activity — BLOOD_Leukemia

Explore this box plot interactively →