Positive regulation of B cell differentiation

Across TCGA cell cohorts, RNA activity of the Positive regulation of B cell differentiation pathway is significantly associated with the RNA expression of multiple genes, with the LUNG_NSCLC_LUSC cohort showing a particularly strong set of associations.

The most reproducible pathway-associated genes across cancer lineages are TRPM4, TSSK4, and TAS2R20, each associated with the pathway in up to 4 cancer types. Since the analysis shows associations rather than directional relationships, both pathway-to-partner and partner-to-pathway views are reported.

Each partner is linked to its corresponding Q-omics profile. The box plot shows the strongest association, TRPM4 grouped by Positive regulation of B cell differentiation-low versus -high activity in LUNG_NSCLC_LUSC.

Pathway-associated genes by consensus

Ranked by combined sampling and lineage consensus. X-score (pathway→partner) and Y-score (partner→pathway) are standardized regression coefficients; both directions are reported because the association is undirected. The reported p-values are derived from the association test.

Lineage	Partner gene	X-score	Y-score	p(X)	p(Y)	Sampling consensus	Lineage consensus
LUNG_NSCLC_LUSC	TRPM4 →	-1.714	-1.501	.006	.003	3	4
SOFT_TISSUE	TSSK4 →	-0.827	-1.416	.004	<.001	3	4
SOFT_TISSUE	TAS2R20 →	-0.565	-1.765	.002	<.001	3	4
PANCREAS	SZT2 →	-0.758	-1.245	.009	.005	3	4
LARGE_INTESTINE	PRIMPOL →	+0.641	+1.039	.006	.005	3	4
LIVER	CBX3 →	+0.678	+1.480	.003	<.001	3	3

Each partner links to its Q-omics profile. Showing the 6 strongest associations by consensus.

TRPM4 by Positive regulation of B cell differentiation activity — LUNG_NSCLC_LUSC

Explore this box plot interactively →