Positive regulation of B cell differentiation

Across TCGA cell cohorts, RNA activity of the Positive regulation of B cell differentiation pathway is significantly associated with the RNA expression of multiple genes, with the PANCREAS cohort showing a particularly strong set of associations.

The most reproducible pathway-associated genes across cancer lineages are MMP14, HMGA2, and NDUFB2, each associated with the pathway in up to 6 cancer types. Since the analysis shows associations rather than directional relationships, both pathway-to-partner and partner-to-pathway views are reported.

Each partner is linked to its corresponding Q-omics profile. The scatter plot shows the strongest association, Positive regulation of B cell differentiation activity versus MMP14 in PANCREAS (Pearson r = 0.21).

Pathway-associated genes by consensus

Ranked by combined sampling and lineage consensus. X-score (pathway→partner) and Y-score (partner→pathway) are standardized regression coefficients; both directions are reported because the association is undirected. The reported p-values are derived from the association test.

Lineage	Partner gene	X-score	Y-score	p(X)	p(Y)	Sampling consensus	Lineage consensus
PANCREAS	MMP14 →	+3.232	+0.379	.001	<.001	3	6
LARGE_INTESTINE	HMGA2 →	+2.595	+0.871	.001	.001	3	4
OESOPHAGUS	NDUFB2 →	-1.163	-0.680	<.001	.003	3	4
SKIN	DUOX1 →	-0.195	-0.276	.001	.003	3	3
SKIN	CERS2 →	-0.484	-0.265	.002	.002	3	3
SKIN	CSNK2A2 →	-0.419	-0.291	.002	<.001	3	3

Each partner links to its Q-omics profile. Showing the 6 strongest associations by consensus.

GO:0045579 vs MMP14 — PANCREAS

Explore this scatter interactively →