Mast cell activation

Across TCGA patient cohorts, RNA activity of the Mast cell activation pathway is significantly associated with the protein abundance of multiple proteins, with the UCEC cohort showing a particularly strong set of associations.

The most reproducible pathway-associated proteins across cancer lineages are RGS19, SAMSN1_S23, and SASH3, each associated with the pathway in up to 10 cancer types. Since the analysis shows associations rather than directional relationships, both pathway-to-partner and partner-to-pathway views are reported.

Each partner is linked to its corresponding Q-omics profile. The scatter plot shows the strongest association, Mast cell activation activity versus RGS19 in UCEC (Pearson r = 0.33).

Pathway-associated proteins by consensus

Ranked by combined sampling and lineage consensus. X-score (pathway→partner) and Y-score (partner→pathway) are standardized regression coefficients; both directions are reported because the association is undirected. The reported p-values are derived from the association test.

Lineage	Partner protein	X-score	Y-score	p(X)	p(Y)	Sampling consensus	Lineage consensus
UCEC	RGS19 →	+0.482	+0.042	<.001	<.001	3	10
LSCC	SAMSN1_S23 →	+0.888	+0.071	<.001	<.001	3	10
OV	SASH3 →	+0.618	+0.056	.001	<.001	3	10
GBM	SKAP2 →	+0.805	+0.077	<.001	<.001	3	10
LSCC	STK10 →	+0.510	+0.072	<.001	<.001	3	10
GBM	TNFAIP8L2 →	+0.661	+0.059	<.001	<.001	3	10

Each partner links to its Q-omics profile. Showing the 6 strongest associations by consensus.

GO:0045576 vs RGS19 — UCEC

Explore this scatter interactively →