Mast cell activation

Across TCGA patient cohorts, RNA activity of the Mast cell activation pathway is significantly associated with the RNA expression of multiple genes, with the GBM cohort showing a particularly strong set of associations.

The most reproducible pathway-associated genes across cancer lineages are ITGAX, FREM2, and FGR, each associated with the pathway in up to 6 cancer types. Since the analysis shows associations rather than directional relationships, both pathway-to-partner and partner-to-pathway views are reported.

Each partner is linked to its corresponding Q-omics profile. The scatter plot shows the strongest association, Mast cell activation activity versus ITGAX in GBM (Pearson r = 0.12).

Pathway-associated genes by consensus

Ranked by combined sampling and lineage consensus. X-score (pathway→partner) and Y-score (partner→pathway) are standardized regression coefficients; both directions are reported because the association is undirected. The reported p-values are derived from the association test.

Lineage	Partner gene	X-score	Y-score	p(X)	p(Y)	Sampling consensus	Lineage consensus
GBM	ITGAX →	+1.032	+0.252	<.001	<.001	3	6
HNSC	FREM2 →	-1.925	-0.217	<.001	<.001	3	6
LSCC	FGR →	+1.243	+0.985	<.001	<.001	3	6
UCEC	KIAA0513 →	+0.635	+0.370	.007	.001	3	5
UCEC	FCGR2A →	+0.507	+0.340	<.001	.002	3	5
GBM	TBXAS1 →	+0.796	+0.181	<.001	<.001	3	5

Each partner links to its Q-omics profile. Showing the 6 strongest associations by consensus.

GO:0045576 vs ITGAX — GBM

Explore this scatter interactively →