Mast cell activation

Across TCGA cell cohorts, RNA activity of the Mast cell activation pathway is significantly associated with the RNA expression of multiple genes, with the BLOOD_Leukemia cohort showing a particularly strong set of associations.

The most reproducible pathway-associated genes across cancer lineages are R3HDM4, RAP1GAP2, and FRMD5, each associated with the pathway in up to 4 cancer types. Since the analysis shows associations rather than directional relationships, both pathway-to-partner and partner-to-pathway views are reported.

Each partner is linked to its corresponding Q-omics profile. The box plot shows the strongest association, R3HDM4 grouped by Mast cell activation-low versus -high activity in BLOOD_Leukemia.

Pathway-associated genes by consensus

Ranked by combined sampling and lineage consensus. X-score (pathway→partner) and Y-score (partner→pathway) are standardized regression coefficients; both directions are reported because the association is undirected. The reported p-values are derived from the association test.

Lineage	Partner gene	X-score	Y-score	p(X)	p(Y)	Sampling consensus	Lineage consensus
BLOOD_Leukemia	R3HDM4 →	-0.773	-1.154	<.001	<.001	3	4
CNS	RAP1GAP2 →	-1.867	-0.912	.002	.003	3	4
OESOPHAGUS	FRMD5 →	-1.633	-1.304	<.001	.001	3	4
STOMACH	ARFGEF1 →	-0.791	-0.855	.004	.007	3	4
SOFT_TISSUE	ENG →	-3.463	-1.494	.005	<.001	3	4
LUNG_NSCLC_LUSC	UBXN1 →	+0.983	+1.235	.002	.003	2	4

Each partner links to its Q-omics profile. Showing the 6 strongest associations by consensus.

R3HDM4 by Mast cell activation activity — BLOOD_Leukemia

Explore this box plot interactively →