Mast cell activation

Across TCGA cell cohorts, RNA activity of the Mast cell activation pathway is significantly associated with the shRNA dependency of multiple genes, with the LUNG_NSCLC_LUSC cohort showing a particularly strong set of associations.

The most reproducible pathway-associated genes across cancer lineages are CSN3, IFNA10, and TMED9, each associated with the pathway in up to 4 cancer types. Since the analysis shows associations rather than directional relationships, both pathway-to-partner and partner-to-pathway views are reported.

Each partner is linked to its corresponding Q-omics profile. The box plot shows the strongest association, CSN3 grouped by Mast cell activation-low versus -high activity in LUNG_NSCLC_LUSC.

Pathway-associated genes by consensus

Ranked by combined sampling and lineage consensus. X-score (pathway→partner) and Y-score (partner→pathway) are standardized regression coefficients; both directions are reported because the association is undirected. The reported p-values are derived from the association test.

Lineage	Partner gene	X-score	Y-score	p(X)	p(Y)	Sampling consensus	Lineage consensus
LUNG_NSCLC_LUSC	CSN3 →	-0.377	-1.671	.005	.002	3	4
BLOOD_Leukemia	IFNA10 →	-0.278	-1.398	<.001	.001	3	4
BLOOD_Leukemia	TMED9 →	-0.205	-1.311	.001	.001	3	3
SKIN	NCAPD2 →	+0.168	+0.635	<.001	.008	3	3
SKIN	PLAT →	-0.299	-0.933	.001	.009	3	3
OESOPHAGUS	ARHGEF10 →	-0.078	-1.090	.006	.001	3	3

Each partner links to its Q-omics profile. Showing the 6 strongest associations by consensus.

CSN3 by Mast cell activation activity — LUNG_NSCLC_LUSC

Explore this box plot interactively →