Positive regulation of cholesterol biosynthetic process

Across TCGA patient cohorts, RNA activity of the Positive regulation of cholesterol biosynthetic process pathway is significantly associated with the RNA expression of multiple genes, with the CCRCC cohort showing a particularly strong set of associations.

The most reproducible pathway-associated genes across cancer lineages are BMP8B, ZDHHC23, and RPL15P2, each associated with the pathway in up to 3 cancer types. Since the analysis shows associations rather than directional relationships, both pathway-to-partner and partner-to-pathway views are reported.

Each partner is linked to its corresponding Q-omics profile. The scatter plot shows the strongest association, Positive regulation of cholesterol biosynthetic process activity versus BMP8B in CCRCC (Pearson r = -0.02).

Pathway-associated genes by consensus

Ranked by combined sampling and lineage consensus. X-score (pathway→partner) and Y-score (partner→pathway) are standardized regression coefficients; both directions are reported because the association is undirected. The reported p-values are derived from the association test.

Lineage	Partner gene	X-score	Y-score	p(X)	p(Y)	Sampling consensus	Lineage consensus
CCRCC	BMP8B →	+0.506	+0.435	.008	.004	3	2
CCRCC	ZDHHC23 →	+0.539	+0.566	.002	<.001	3	2
CCRCC	RPL15P2 →	-0.285	-0.459	.007	.002	3	2
UCEC	STARD7 →	+0.352	+0.619	.001	.006	3	2
LUAD	DRP2 →	-0.385	-0.537	<.001	.002	3	2
LUAD	KIF20A →	-0.819	-0.619	.001	.003	3	2

Each partner links to its Q-omics profile. Showing the 6 strongest associations by consensus.

GO:0045542 vs BMP8B — CCRCC

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