Positive regulation of cholesterol biosynthetic process

Across TCGA patient cohorts, RNA activity of the Positive regulation of cholesterol biosynthetic process pathway is significantly associated with the protein abundance of multiple proteins, with the OV cohort showing a particularly strong set of associations.

The most reproducible pathway-associated proteins across cancer lineages are NADK_S46, CLUAP1_S409, and RHBDF2_S328, each associated with the pathway in up to 3 cancer types. Since the analysis shows associations rather than directional relationships, both pathway-to-partner and partner-to-pathway views are reported.

Each partner is linked to its corresponding Q-omics profile. The scatter plot shows the strongest association, Positive regulation of cholesterol biosynthetic process activity versus NADK_S46 in OV (Pearson r = 0.27).

Pathway-associated proteins by consensus

Ranked by combined sampling and lineage consensus. X-score (pathway→partner) and Y-score (partner→pathway) are standardized regression coefficients; both directions are reported because the association is undirected. The reported p-values are derived from the association test.

Lineage	Partner protein	X-score	Y-score	p(X)	p(Y)	Sampling consensus	Lineage consensus
OV	NADK_S46 →	+1.106	+0.899	<.001	<.001	3	3
OV	CLUAP1_S409 →	-0.985	-0.898	<.001	<.001	3	3
LUAD	RHBDF2_S328 →	+0.611	+0.685	.001	<.001	3	2
CCRCC	SAMD14_S130 →	-0.402	-0.573	<.001	.001	3	2
LUAD	SRRM1_S549 →	-0.945	-0.877	<.001	<.001	3	2
CCRCC	TJP1_S1278 →	-1.012	-0.685	<.001	.002	3	2

Each partner links to its Q-omics profile. Showing the 6 strongest associations by consensus.

GO:0045542 vs NADK_S46 — OV

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