Positive regulation of cholesterol biosynthetic process

Across TCGA cell cohorts, RNA activity of the Positive regulation of cholesterol biosynthetic process pathway is significantly associated with the RNA expression of multiple genes, with the LIVER cohort showing a particularly strong set of associations.

The most reproducible pathway-associated genes across cancer lineages are SPRED1, PROCR, and KMT2A, each associated with the pathway in up to 5 cancer types. Since the analysis shows associations rather than directional relationships, both pathway-to-partner and partner-to-pathway views are reported.

Each partner is linked to its corresponding Q-omics profile. The scatter plot shows the strongest association, Positive regulation of cholesterol biosynthetic process activity versus SPRED1 in LIVER (Pearson r = 0.73).

Pathway-associated genes by consensus

Ranked by combined sampling and lineage consensus. X-score (pathway→partner) and Y-score (partner→pathway) are standardized regression coefficients; both directions are reported because the association is undirected. The reported p-values are derived from the association test.

Lineage	Partner gene	X-score	Y-score	p(X)	p(Y)	Sampling consensus	Lineage consensus
LIVER	SPRED1 →	+1.125	+0.235	.003	.002	3	5
UPPER_AERODIGESTIVE_TRACT	PROCR →	+0.870	+0.170	.008	.005	3	5
CNS	KMT2A →	+0.565	+0.166	.004	<.001	3	4
BLOOD_Myeloma	NUP43 →	+0.724	+0.273	.002	<.001	3	4
CNS	DENND2D →	-0.730	-0.144	.009	.003	2	5
CNS	CKAP5 →	+0.604	+0.248	<.001	<.001	3	4

Each partner links to its Q-omics profile. Showing the 6 strongest associations by consensus.

GO:0045542 vs SPRED1 — LIVER

Explore this scatter interactively →