Regulation of cholesterol biosynthetic process

Across TCGA cell cohorts, RNA activity of the Regulation of cholesterol biosynthetic process pathway is significantly associated with the RNA expression of multiple genes, with the LUNG_NSCLC_LUAD cohort showing a particularly strong set of associations.

The most reproducible pathway-associated genes across cancer lineages are ZNF426, SLC37A3, and ADCK2, each associated with the pathway in up to 4 cancer types. Since the analysis shows associations rather than directional relationships, both pathway-to-partner and partner-to-pathway views are reported.

Each partner is linked to its corresponding Q-omics profile. The box plot shows the strongest association, ZNF426 grouped by Regulation of cholesterol biosynthetic process-low versus -high activity in LUNG_NSCLC_LUAD.

Pathway-associated genes by consensus

Ranked by combined sampling and lineage consensus. X-score (pathway→partner) and Y-score (partner→pathway) are standardized regression coefficients; both directions are reported because the association is undirected. The reported p-values are derived from the association test.

Lineage	Partner gene	X-score	Y-score	p(X)	p(Y)	Sampling consensus	Lineage consensus
LUNG_NSCLC_LUAD	ZNF426 →	-0.721	-0.169	<.001	.001	3	4
BREAST	SLC37A3 →	+0.774	+0.198	<.001	.004	3	3
LUNG_SCLC	ADCK2 →	+0.978	+0.324	.006	.007	3	3
LUNG_SCLC	LRTOMT →	+0.846	+0.289	.003	.001	3	3
OVARY	SPIN1 →	-0.586	-0.599	.003	.004	3	3
UPPER_AERODIGESTIVE_TRACT	ARHGEF16 →	+1.365	+0.330	.003	.002	3	3

Each partner links to its Q-omics profile. Showing the 6 strongest associations by consensus.

ZNF426 by Regulation of cholesterol biosynthetic process activity — LUNG_NSCLC_LUAD

Explore this box plot interactively →