Regulation of cholesterol biosynthetic process

Across TCGA cell cohorts, RNA activity of the Regulation of cholesterol biosynthetic process pathway is significantly associated with the RNA expression of multiple genes, with the BREAST cohort showing a particularly strong set of associations.

The most reproducible pathway-associated genes across cancer lineages are ERLIN2, ELP4, and LSM1, each associated with the pathway in up to 6 cancer types. Since the analysis shows associations rather than directional relationships, both pathway-to-partner and partner-to-pathway views are reported.

Each partner is linked to its corresponding Q-omics profile. The scatter plot shows the strongest association, Regulation of cholesterol biosynthetic process activity versus ERLIN2 in BREAST (Pearson r = 0.50).

Pathway-associated genes by consensus

Ranked by combined sampling and lineage consensus. X-score (pathway→partner) and Y-score (partner→pathway) are standardized regression coefficients; both directions are reported because the association is undirected. The reported p-values are derived from the association test.

Lineage	Partner gene	X-score	Y-score	p(X)	p(Y)	Sampling consensus	Lineage consensus
BREAST	ERLIN2 →	+1.450	+0.372	<.001	<.001	3	6
BLOOD_Myeloma	ELP4 →	+0.696	+0.253	.003	.009	3	6
STOMACH	LSM1 →	+0.963	+0.257	.001	.001	3	5
BREAST	BAG4 →	+1.168	+0.320	<.001	<.001	3	5
LUNG_SCLC	IFTAP →	+2.081	+0.397	.003	<.001	3	5
LUNG_NSCLC_LUSC	PPM1F →	+1.520	+0.241	<.001	<.001	3	5

Each partner links to its Q-omics profile. Showing the 6 strongest associations by consensus.

GO:0045540 vs ERLIN2 — BREAST

Explore this scatter interactively →