Photoreceptor cell maintenance

Across TCGA patient cohorts, RNA activity of the Photoreceptor cell maintenance pathway is significantly associated with the protein abundance of multiple proteins, with the UCEC cohort showing a particularly strong set of associations.

The most reproducible pathway-associated proteins across cancer lineages are BBS7, FERMT3, and ARHGAP15, each associated with the pathway in up to 6 cancer types. Since the analysis shows associations rather than directional relationships, both pathway-to-partner and partner-to-pathway views are reported.

Each partner is linked to its corresponding Q-omics profile. The scatter plot shows the strongest association, Photoreceptor cell maintenance activity versus BBS7 in UCEC (Pearson r = 0.37).

Pathway-associated proteins by consensus

Ranked by combined sampling and lineage consensus. X-score (pathway→partner) and Y-score (partner→pathway) are standardized regression coefficients; both directions are reported because the association is undirected. The reported p-values are derived from the association test.

Lineage	Partner protein	X-score	Y-score	p(X)	p(Y)	Sampling consensus	Lineage consensus
UCEC	BBS7 →	+0.481	+0.066	<.001	<.001	3	6
GBM	FERMT3 →	-0.532	-0.051	.002	.003	3	6
GBM	ARHGAP15 →	-0.634	-0.052	.004	.005	3	6
UCEC	OSCP1 →	+0.708	+0.071	<.001	<.001	3	6
LUAD	DEF6 →	-0.190	-0.042	.002	.001	3	6
UCEC	BBS2 →	+0.471	+0.057	<.001	<.001	3	5

Each partner links to its Q-omics profile. Showing the 6 strongest associations by consensus.

GO:0045494 vs BBS7 — UCEC

Explore this scatter interactively →