Locomotor rhythm

Across TCGA cell cohorts, RNA activity of the Locomotor rhythm pathway is significantly associated with the RNA expression of multiple genes, with the BLOOD_Leukemia cohort showing a particularly strong set of associations.

The most reproducible pathway-associated genes across cancer lineages are CD55, IFT80, and FNDC3B, each associated with the pathway in up to 3 cancer types. Since the analysis shows associations rather than directional relationships, both pathway-to-partner and partner-to-pathway views are reported.

Each partner is linked to its corresponding Q-omics profile. The scatter plot shows the strongest association, Locomotor rhythm activity versus CD55 in BLOOD_Leukemia (Pearson r = -0.51).

Pathway-associated genes by consensus

Ranked by combined sampling and lineage consensus. X-score (pathway→partner) and Y-score (partner→pathway) are standardized regression coefficients; both directions are reported because the association is undirected. The reported p-values are derived from the association test.

Lineage	Partner gene	X-score	Y-score	p(X)	p(Y)	Sampling consensus	Lineage consensus
BLOOD_Leukemia	CD55 →	-2.909	-0.945	<.001	.003	3	3
LARGE_INTESTINE	IFT80 →	+0.871	+0.204	.007	.006	3	3
BLOOD_Leukemia	FNDC3B →	-1.903	-0.948	<.001	.004	3	2
BLOOD_Leukemia	GNAS →	+0.852	+0.903	.006	.006	3	2
BLOOD_Leukemia	UVRAG →	-1.130	-1.238	<.001	.003	3	2
BLOOD_Leukemia	NEU1 →	-0.973	-0.691	<.001	.004	3	2

Each partner links to its Q-omics profile. Showing the 6 strongest associations by consensus.

GO:0045475 vs CD55 — BLOOD_Leukemia

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