Response to ether

Across TCGA patient cohorts, RNA activity of the Response to ether pathway is significantly associated with the protein abundance of multiple proteins, with the GBM cohort showing a particularly strong set of associations.

The most reproducible pathway-associated proteins across cancer lineages are DEF6, LGALS9, and RCSD1_S298, each associated with the pathway in up to 8 cancer types. Since the analysis shows associations rather than directional relationships, both pathway-to-partner and partner-to-pathway views are reported.

Each partner is linked to its corresponding Q-omics profile. The scatter plot shows the strongest association, Response to ether activity versus DEF6 in GBM (Pearson r = 0.66).

Pathway-associated proteins by consensus

Ranked by combined sampling and lineage consensus. X-score (pathway→partner) and Y-score (partner→pathway) are standardized regression coefficients; both directions are reported because the association is undirected. The reported p-values are derived from the association test.

Lineage	Partner protein	X-score	Y-score	p(X)	p(Y)	Sampling consensus	Lineage consensus
GBM	DEF6 →	+0.511	+0.075	<.001	<.001	3	8
GBM	LGALS9 →	+0.457	+0.061	<.001	<.001	3	8
LSCC	RCSD1_S298 →	+0.594	+0.082	<.001	<.001	3	7
LSCC	DOCK2_S1685 →	+0.768	+0.094	<.001	<.001	3	7
GBM	SH3BP1 →	+0.273	+0.064	<.001	<.001	3	7
LSCC	CYBB →	+0.772	+0.095	<.001	<.001	3	7

Each partner links to its Q-omics profile. Showing the 6 strongest associations by consensus.

GO:0045472 vs DEF6 — GBM

Explore this scatter interactively →