Response to ether

Across TCGA patient cohorts, RNA activity of the Response to ether pathway is significantly associated with the protein abundance of multiple proteins, with the OV cohort showing a particularly strong set of associations.

The most reproducible pathway-associated proteins across cancer lineages are TCP11L1_S55, TLN1_S2040, and TNKS1BP1_S1328, each associated with the pathway in up to 4 cancer types. Since the analysis shows associations rather than directional relationships, both pathway-to-partner and partner-to-pathway views are reported.

Each partner is linked to its corresponding Q-omics profile. The scatter plot shows the strongest association, Response to ether activity versus TCP11L1_S55 in OV (Pearson r = -0.27).

Pathway-associated proteins by consensus

Ranked by combined sampling and lineage consensus. X-score (pathway→partner) and Y-score (partner→pathway) are standardized regression coefficients; both directions are reported because the association is undirected. The reported p-values are derived from the association test.

Lineage	Partner protein	X-score	Y-score	p(X)	p(Y)	Sampling consensus	Lineage consensus
OV	TCP11L1_S55 →	-0.626	-0.286	.005	.003	2	4
UCEC	TLN1_S2040 →	-1.156	-0.184	<.001	<.001	3	3
OV	TNKS1BP1_S1328 →	-2.039	-0.498	<.001	<.001	3	3
UCEC	TNS1_S1381 →	-1.187	-0.185	<.001	<.001	3	3
UCEC	YLPM1_S756 →	+0.650	+0.181	.001	.001	3	3
UCEC	ZC3H14_S343 →	+0.644	+0.238	<.001	<.001	3	3

Each partner links to its Q-omics profile. Showing the 6 strongest associations by consensus.

GO:0045472 vs TCP11L1_S55 — OV

Explore this scatter interactively →