Response to ether

Across TCGA cell cohorts, RNA activity of the Response to ether pathway is significantly associated with the RNA expression of multiple genes, with the LUNG_SCLC cohort showing a particularly strong set of associations.

The most reproducible pathway-associated genes across cancer lineages are TEX29, PLOD2, and FDXR, each associated with the pathway in up to 5 cancer types. Since the analysis shows associations rather than directional relationships, both pathway-to-partner and partner-to-pathway views are reported.

Each partner is linked to its corresponding Q-omics profile. The box plot shows the strongest association, TEX29 grouped by Response to ether-low versus -high activity in LUNG_SCLC.

Pathway-associated genes by consensus

Ranked by combined sampling and lineage consensus. X-score (pathway→partner) and Y-score (partner→pathway) are standardized regression coefficients; both directions are reported because the association is undirected. The reported p-values are derived from the association test.

Lineage	Partner gene	X-score	Y-score	p(X)	p(Y)	Sampling consensus	Lineage consensus
LUNG_SCLC	TEX29 →	-0.578	-0.331	<.001	<.001	3	5
LUNG_NSCLC_LUAD	PLOD2 →	-1.328	-0.643	.003	.002	3	4
SKIN	FDXR →	+1.125	+0.828	<.001	.002	3	3
SKIN	FMNL1 →	-1.422	-0.707	.002	.004	3	3
BLOOD_Myeloma	POLR1D →	+0.816	+1.148	.002	.001	3	3
PANCREAS	KLHL17 →	-1.222	-0.889	.002	.009	3	3

Each partner links to its Q-omics profile. Showing the 6 strongest associations by consensus.

TEX29 by Response to ether activity — LUNG_SCLC

Explore this box plot interactively →