Response to ether

Across TCGA cell cohorts, RNA activity of the Response to ether pathway is significantly associated with the RNA expression of multiple genes, with the UPPER_AERODIGESTIVE_TRACT cohort showing a particularly strong set of associations.

The most reproducible pathway-associated genes across cancer lineages are RPL3, RPS9, and EEF1A1, each associated with the pathway in up to 10 cancer types. Since the analysis shows associations rather than directional relationships, both pathway-to-partner and partner-to-pathway views are reported.

Each partner is linked to its corresponding Q-omics profile. The scatter plot shows the strongest association, Response to ether activity versus RPL3 in UPPER_AERODIGESTIVE_TRACT (Pearson r = 0.59).

Pathway-associated genes by consensus

Ranked by combined sampling and lineage consensus. X-score (pathway→partner) and Y-score (partner→pathway) are standardized regression coefficients; both directions are reported because the association is undirected. The reported p-values are derived from the association test.

Lineage	Partner gene	X-score	Y-score	p(X)	p(Y)	Sampling consensus	Lineage consensus
UPPER_AERODIGESTIVE_TRACT	RPL3 →	+0.908	+0.233	.006	.005	2	10
PANCREAS	RPS9 →	+0.723	+0.158	.001	.005	3	8
UPPER_AERODIGESTIVE_TRACT	EEF1A1 →	+0.947	+0.269	<.001	.001	3	8
CNS	RPL13A →	+0.720	+0.149	.004	.001	3	7
PANCREAS	EEF1B2 →	+0.645	+0.160	<.001	<.001	3	7
STOMACH	ATP5F1D →	+1.128	+0.335	.004	.009	3	6

Each partner links to its Q-omics profile. Showing the 6 strongest associations by consensus.

GO:0045472 vs RPL3 — UPPER_AERODIGESTIVE_TRACT

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