Response to ethanol

Across TCGA patient cohorts, RNA activity of the Response to ethanol pathway is significantly associated with the protein abundance of multiple proteins, with the GBM cohort showing a particularly strong set of associations.

The most reproducible pathway-associated proteins across cancer lineages are TNFAIP8L2, WAS, and CORO1A, each associated with the pathway in up to 7 cancer types. Since the analysis shows associations rather than directional relationships, both pathway-to-partner and partner-to-pathway views are reported.

Each partner is linked to its corresponding Q-omics profile. The scatter plot shows the strongest association, Response to ethanol activity versus TNFAIP8L2 in GBM (Pearson r = 0.55).

Pathway-associated proteins by consensus

Ranked by combined sampling and lineage consensus. X-score (pathway→partner) and Y-score (partner→pathway) are standardized regression coefficients; both directions are reported because the association is undirected. The reported p-values are derived from the association test.

Lineage	Partner protein	X-score	Y-score	p(X)	p(Y)	Sampling consensus	Lineage consensus
GBM	TNFAIP8L2 →	+0.842	+0.059	<.001	<.001	3	7
GBM	WAS →	+0.659	+0.046	<.001	<.001	3	7
GBM	CORO1A →	+0.610	+0.052	<.001	<.001	3	7
LSCC	MYO1F_S1023 →	+0.989	+0.052	<.001	<.001	3	7
GBM	ARHGAP45 →	+0.570	+0.039	<.001	<.001	3	7
LSCC	GEM_S23 →	+0.823	+0.039	.001	.001	3	7

Each partner links to its Q-omics profile. Showing the 6 strongest associations by consensus.

GO:0045471 vs TNFAIP8L2 — GBM

Explore this scatter interactively →