Response to ethanol

Across TCGA cell cohorts, RNA activity of the Response to ethanol pathway is significantly associated with the RNA expression of multiple genes, with the SOFT_TISSUE cohort showing a particularly strong set of associations.

The most reproducible pathway-associated genes across cancer lineages are AP1S3, TMEM203, and LOX, each associated with the pathway in up to 6 cancer types. Since the analysis shows associations rather than directional relationships, both pathway-to-partner and partner-to-pathway views are reported.

Each partner is linked to its corresponding Q-omics profile. The box plot shows the strongest association, AP1S3 grouped by Response to ethanol-low versus -high activity in SOFT_TISSUE.

Pathway-associated genes by consensus

Ranked by combined sampling and lineage consensus. X-score (pathway→partner) and Y-score (partner→pathway) are standardized regression coefficients; both directions are reported because the association is undirected. The reported p-values are derived from the association test.

Lineage	Partner gene	X-score	Y-score	p(X)	p(Y)	Sampling consensus	Lineage consensus
SOFT_TISSUE	AP1S3 →	+2.869	+0.224	<.001	.001	3	6
LUNG_SCLC	TMEM203 →	-0.627	-0.156	.007	.009	2	6
SOFT_TISSUE	LOX →	-4.377	-0.225	<.001	.001	3	5
SOFT_TISSUE	VLDLR →	-2.611	-0.301	.003	<.001	3	5
BONE	PFKM →	-1.036	-0.176	.006	.008	3	5
BLOOD_Leukemia	PARD3B →	-0.774	-0.120	.008	.005	3	5

Each partner links to its Q-omics profile. Showing the 6 strongest associations by consensus.

AP1S3 by Response to ethanol activity — SOFT_TISSUE

Explore this box plot interactively →