Cell redox homeostasis

Across TCGA patient cohorts, RNA activity of the Cell redox homeostasis pathway is significantly associated with the RNA expression of multiple genes, with the UVM cohort showing a particularly strong set of associations.

The most reproducible pathway-associated genes across cancer lineages are AHSA2P, STAG3L5P, and ACTG1P3, each associated with the pathway in up to 29 cancer types. Since the analysis shows associations rather than directional relationships, both pathway-to-partner and partner-to-pathway views are reported.

Each partner is linked to its corresponding Q-omics profile. The scatter plot shows the strongest association, Cell redox homeostasis activity versus AHSA2P in UVM (Pearson r = 0.82).

Pathway-associated genes by consensus

Ranked by combined sampling and lineage consensus. X-score (pathway→partner) and Y-score (partner→pathway) are standardized regression coefficients; both directions are reported because the association is undirected. The reported p-values are derived from the association test.

Lineage	Partner gene	X-score	Y-score	p(X)	p(Y)	Sampling consensus	Lineage consensus
UVM	AHSA2P →	+1.861	+0.052	<.001	<.001	3	29
UVM	STAG3L5P →	+1.545	+0.054	<.001	<.001	3	28
UVM	ACTG1P3 →	+0.506	+0.053	<.001	<.001	3	28
KIRC	KIF1C-AS1 →	+0.592	+0.036	<.001	<.001	3	28
UVM	RHOQ-AS1 →	+0.615	+0.049	<.001	<.001	3	27
UVM	MRNIP →	+1.048	+0.054	<.001	<.001	3	27

Each partner links to its Q-omics profile. Showing the 6 strongest associations by consensus.

GO:0045454 vs AHSA2P — UVM

Explore this scatter interactively →