Cell redox homeostasis

Across TCGA patient cohorts, RNA activity of the Cell redox homeostasis pathway is significantly associated with the RNA expression of multiple genes, with the HNSC cohort showing a particularly strong set of associations.

The most reproducible pathway-associated genes across cancer lineages are CCNJL, INPP5B, and CLASRP, each associated with the pathway in up to 5 cancer types. Since the analysis shows associations rather than directional relationships, both pathway-to-partner and partner-to-pathway views are reported.

Each partner is linked to its corresponding Q-omics profile. The scatter plot shows the strongest association, Cell redox homeostasis activity versus CCNJL in HNSC (Pearson r = -0.24).

Pathway-associated genes by consensus

Ranked by combined sampling and lineage consensus. X-score (pathway→partner) and Y-score (partner→pathway) are standardized regression coefficients; both directions are reported because the association is undirected. The reported p-values are derived from the association test.

Lineage	Partner gene	X-score	Y-score	p(X)	p(Y)	Sampling consensus	Lineage consensus
HNSC	CCNJL →	-0.567	-0.057	.001	.006	3	5
LSCC	INPP5B →	-0.279	-0.072	.007	.003	3	4
OV	CLASRP →	-0.639	-0.112	.002	<.001	3	4
BRCA	CMTM3 →	-0.609	-0.149	.002	<.001	3	4
BRCA	AGAP4 →	-0.467	-0.135	.001	<.001	3	4
OV	CCDC8 →	-0.837	-0.114	.003	<.001	3	4

Each partner links to its Q-omics profile. Showing the 6 strongest associations by consensus.

GO:0045454 vs CCNJL — HNSC

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