Cell redox homeostasis

Across TCGA cell cohorts, RNA activity of the Cell redox homeostasis pathway is significantly associated with the shRNA dependency of multiple genes, with the BONE cohort showing a particularly strong set of associations.

The most reproducible pathway-associated genes across cancer lineages are PRDX1, PPP3CC, and ADCK5, each associated with the pathway in up to 5 cancer types. Since the analysis shows associations rather than directional relationships, both pathway-to-partner and partner-to-pathway views are reported.

Each partner is linked to its corresponding Q-omics profile. The box plot shows the strongest association, PRDX1 grouped by Cell redox homeostasis-low versus -high activity in BONE.

Pathway-associated genes by consensus

Ranked by combined sampling and lineage consensus. X-score (pathway→partner) and Y-score (partner→pathway) are standardized regression coefficients; both directions are reported because the association is undirected. The reported p-values are derived from the association test.

Lineage	Partner gene	X-score	Y-score	p(X)	p(Y)	Sampling consensus	Lineage consensus
BONE	PRDX1 →	-0.472	-1.575	.003	<.001	3	5
CNS	PPP3CC →	-0.142	-0.799	.004	<.001	3	4
PANCREAS	ADCK5 →	+0.221	+0.749	<.001	.008	3	4
LARGE_INTESTINE	PRDX4 →	-0.271	-1.221	.003	.008	2	5
CNS	PEX1 →	-0.361	-0.863	<.001	<.001	3	3
CNS	UBR7 →	-0.170	-0.810	.005	.007	3	3

Each partner links to its Q-omics profile. Showing the 6 strongest associations by consensus.

PRDX1 by Cell redox homeostasis activity — BONE

Explore this box plot interactively →