Cell redox homeostasis

Across TCGA cell cohorts, RNA activity of the Cell redox homeostasis pathway is significantly associated with the RNA expression of multiple genes, with the UPPER_AERODIGESTIVE_TRACT cohort showing a particularly strong set of associations.

The most reproducible pathway-associated genes across cancer lineages are DNAJB14, IKBIP, and IL17D, each associated with the pathway in up to 5 cancer types. Since the analysis shows associations rather than directional relationships, both pathway-to-partner and partner-to-pathway views are reported.

Each partner is linked to its corresponding Q-omics profile. The box plot shows the strongest association, DNAJB14 grouped by Cell redox homeostasis-low versus -high activity in UPPER_AERODIGESTIVE_TRACT.

Pathway-associated genes by consensus

Ranked by combined sampling and lineage consensus. X-score (pathway→partner) and Y-score (partner→pathway) are standardized regression coefficients; both directions are reported because the association is undirected. The reported p-values are derived from the association test.

Lineage	Partner gene	X-score	Y-score	p(X)	p(Y)	Sampling consensus	Lineage consensus
UPPER_AERODIGESTIVE_TRACT	DNAJB14 →	+1.021	+0.979	.009	.008	3	5
BLOOD_Lymphoma	IKBIP →	+1.147	+1.303	.003	.008	3	5
BLOOD_Lymphoma	IL17D →	-1.099	-1.343	.002	<.001	3	5
UPPER_AERODIGESTIVE_TRACT	SPATS2 →	+1.063	+1.217	.002	.005	2	5
LUNG_NSCLC_LUSC	ZUP1 →	+0.713	+0.801	.002	.007	3	4
BONE	WWC2 →	+1.639	+1.343	.004	<.001	3	4

Each partner links to its Q-omics profile. Showing the 6 strongest associations by consensus.

DNAJB14 by Cell redox homeostasis activity — UPPER_AERODIGESTIVE_TRACT

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