Cell redox homeostasis

Across TCGA cell cohorts, RNA activity of the Cell redox homeostasis pathway is significantly associated with the RNA expression of multiple genes, with the OVARY cohort showing a particularly strong set of associations.

The most reproducible pathway-associated genes across cancer lineages are GSR, COX18, and ACYP1, each associated with the pathway in up to 8 cancer types. Since the analysis shows associations rather than directional relationships, both pathway-to-partner and partner-to-pathway views are reported.

Each partner is linked to its corresponding Q-omics profile. The scatter plot shows the strongest association, Cell redox homeostasis activity versus GSR in OVARY (Pearson r = 0.42).

Pathway-associated genes by consensus

Ranked by combined sampling and lineage consensus. X-score (pathway→partner) and Y-score (partner→pathway) are standardized regression coefficients; both directions are reported because the association is undirected. The reported p-values are derived from the association test.

Lineage	Partner gene	X-score	Y-score	p(X)	p(Y)	Sampling consensus	Lineage consensus
OVARY	GSR →	+1.041	+0.306	<.001	<.001	3	8
OVARY	COX18 →	+0.672	+0.302	<.001	<.001	3	6
URINARY_TRACT	ACYP1 →	+1.056	+0.493	.002	.001	3	5
LUNG_NSCLC_LUSC	MAP2K6 →	+2.568	+0.465	.002	.002	3	5
LUNG_NSCLC_LUSC	CRACD →	+1.273	+0.345	.006	.004	3	5
UPPER_AERODIGESTIVE_TRACT	MRPL44 →	+0.865	+0.318	<.001	.005	3	5

Each partner links to its Q-omics profile. Showing the 6 strongest associations by consensus.

GO:0045454 vs GSR — OVARY

Explore this scatter interactively →