Bone resorption

Across TCGA patient cohorts, RNA activity of the Bone resorption pathway is significantly associated with the RNA expression of multiple genes, with the BRCA cohort showing a particularly strong set of associations.

The most reproducible pathway-associated genes across cancer lineages are SPP1, TLR2, and ITGAM, each associated with the pathway in up to 9 cancer types. Since the analysis shows associations rather than directional relationships, both pathway-to-partner and partner-to-pathway views are reported.

Each partner is linked to its corresponding Q-omics profile. The scatter plot shows the strongest association, Bone resorption activity versus SPP1 in BRCA (Pearson r = -0.14).

Pathway-associated genes by consensus

Ranked by combined sampling and lineage consensus. X-score (pathway→partner) and Y-score (partner→pathway) are standardized regression coefficients; both directions are reported because the association is undirected. The reported p-values are derived from the association test.

Lineage	Partner gene	X-score	Y-score	p(X)	p(Y)	Sampling consensus	Lineage consensus
BRCA	SPP1 →	+1.535	+0.298	<.001	<.001	3	9
OV	TLR2 →	+0.728	+0.251	.003	.009	3	7
OV	ITGAM →	+0.947	+0.270	.001	.007	3	7
LSCC	TREM1 →	+0.882	+0.315	<.001	<.001	3	7
GBM	VSIG4 →	+1.155	+0.229	<.001	<.001	3	7
BRCA	CLEC5A →	+0.694	+0.276	<.001	<.001	3	6

Each partner links to its Q-omics profile. Showing the 6 strongest associations by consensus.

GO:0045453 vs SPP1 — BRCA

Explore this scatter interactively →