Bone resorption

Across TCGA cell cohorts, RNA activity of the Bone resorption pathway is significantly associated with the RNA expression of multiple genes, with the LIVER cohort showing a particularly strong set of associations.

The most reproducible pathway-associated genes across cancer lineages are RAC2, TPP1, and ADAMTS16, each associated with the pathway in up to 5 cancer types. Since the analysis shows associations rather than directional relationships, both pathway-to-partner and partner-to-pathway views are reported.

Each partner is linked to its corresponding Q-omics profile. The scatter plot shows the strongest association, Bone resorption activity versus RAC2 in LIVER (Pearson r = 0.85).

Pathway-associated genes by consensus

Ranked by combined sampling and lineage consensus. X-score (pathway→partner) and Y-score (partner→pathway) are standardized regression coefficients; both directions are reported because the association is undirected. The reported p-values are derived from the association test.

Lineage	Partner gene	X-score	Y-score	p(X)	p(Y)	Sampling consensus	Lineage consensus
LIVER	RAC2 →	+6.147	+0.440	<.001	<.001	3	5
BLOOD_Leukemia	TPP1 →	+1.223	+0.257	<.001	<.001	3	5
LIVER	ADAMTS16 →	+2.406	+0.352	<.001	<.001	3	4
LIVER	BAG3 →	+1.426	+0.467	<.001	.001	3	4
LIVER	CTSB →	+2.406	+0.409	.003	.005	2	5
LIVER	SERPINB8 →	+2.662	+0.465	.002	<.001	3	4

Each partner links to its Q-omics profile. Showing the 6 strongest associations by consensus.

GO:0045453 vs RAC2 — LIVER

Explore this scatter interactively →