Myoblast differentiation

Across TCGA patient cohorts, RNA activity of the Myoblast differentiation pathway is significantly associated with the protein abundance of multiple proteins, with the GBM cohort showing a particularly strong set of associations.

The most reproducible pathway-associated proteins across cancer lineages are RBM47, CLINT1, and RIOK2_S337, each associated with the pathway in up to 7 cancer types. Since the analysis shows associations rather than directional relationships, both pathway-to-partner and partner-to-pathway views are reported.

Each partner is linked to its corresponding Q-omics profile. The scatter plot shows the strongest association, Myoblast differentiation activity versus RBM47 in GBM (Pearson r = -0.11).

Pathway-associated proteins by consensus

Ranked by combined sampling and lineage consensus. X-score (pathway→partner) and Y-score (partner→pathway) are standardized regression coefficients; both directions are reported because the association is undirected. The reported p-values are derived from the association test.

Lineage	Partner protein	X-score	Y-score	p(X)	p(Y)	Sampling consensus	Lineage consensus
GBM	RBM47 →	-0.512	-0.031	<.001	<.001	3	7
BRCA	CLINT1 →	-0.204	-0.020	.005	.005	3	6
PDAC	RIOK2_S337 →	-0.270	-0.023	.003	.005	2	6
GBM	PDXDC1 →	-0.244	-0.030	.001	.001	3	5
OV	RPL26 →	-0.545	-0.042	<.001	<.001	3	5
HNSC	CERS4 →	-0.512	-0.049	<.001	<.001	3	5

Each partner links to its Q-omics profile. Showing the 6 strongest associations by consensus.

GO:0045445 vs RBM47 — GBM

Explore this scatter interactively →