Myoblast differentiation

Across TCGA cell cohorts, RNA activity of the Myoblast differentiation pathway is significantly associated with the RNA expression of multiple genes, with the LUNG_NSCLC_LUSC cohort showing a particularly strong set of associations.

The most reproducible pathway-associated genes across cancer lineages are ATXN7L2, SPARCL1, and FABP4, each associated with the pathway in up to 3 cancer types. Since the analysis shows associations rather than directional relationships, both pathway-to-partner and partner-to-pathway views are reported.

Each partner is linked to its corresponding Q-omics profile. The box plot shows the strongest association, ATXN7L2 grouped by Myoblast differentiation-low versus -high activity in LUNG_NSCLC_LUSC.

Pathway-associated genes by consensus

Ranked by combined sampling and lineage consensus. X-score (pathway→partner) and Y-score (partner→pathway) are standardized regression coefficients; both directions are reported because the association is undirected. The reported p-values are derived from the association test.

Lineage	Partner gene	X-score	Y-score	p(X)	p(Y)	Sampling consensus	Lineage consensus
LUNG_NSCLC_LUSC	ATXN7L2 →	-0.411	-0.180	.007	.009	3	3
BLOOD_Myeloma	SPARCL1 →	+1.103	+0.332	.002	<.001	3	2
BLOOD_Myeloma	FABP4 →	-0.140	-1.248	.003	.002	3	2
OESOPHAGUS	RPL11 →	-0.473	-0.289	.002	.003	2	3
OESOPHAGUS	INSIG1 →	+1.328	+0.290	.005	.004	3	2
OESOPHAGUS	MYCBP2 →	-0.792	-0.293	.001	.005	3	2

Each partner links to its Q-omics profile. Showing the 6 strongest associations by consensus.

ATXN7L2 by Myoblast differentiation activity — LUNG_NSCLC_LUSC

Explore this box plot interactively →