Myoblast differentiation

Across TCGA cell cohorts, RNA activity of the Myoblast differentiation pathway is significantly associated with the RNA expression of multiple genes, with the LIVER cohort showing a particularly strong set of associations.

The most reproducible pathway-associated genes across cancer lineages are LEPROT, AHNAK, and ITGB1, each associated with the pathway in up to 7 cancer types. Since the analysis shows associations rather than directional relationships, both pathway-to-partner and partner-to-pathway views are reported.

Each partner is linked to its corresponding Q-omics profile. The scatter plot shows the strongest association, Myoblast differentiation activity versus LEPROT in LIVER (Pearson r = 0.81).

Pathway-associated genes by consensus

Ranked by combined sampling and lineage consensus. X-score (pathway→partner) and Y-score (partner→pathway) are standardized regression coefficients; both directions are reported because the association is undirected. The reported p-values are derived from the association test.

Lineage	Partner gene	X-score	Y-score	p(X)	p(Y)	Sampling consensus	Lineage consensus
LIVER	LEPROT →	+1.608	+0.242	.003	.002	3	7
BLOOD_Lymphoma	AHNAK →	+3.164	+0.199	<.001	<.001	3	6
LIVER	ITGB1 →	+1.995	+0.243	.009	.006	2	7
BLOOD_Lymphoma	F2R →	+2.359	+0.205	.005	.004	3	6
LUNG_SCLC	RHOC →	+2.360	+0.179	.002	.008	3	6
BLOOD_Lymphoma	SLC30A1 →	+1.002	+0.208	.001	<.001	3	6

Each partner links to its Q-omics profile. Showing the 6 strongest associations by consensus.

GO:0045445 vs LEPROT — LIVER

Explore this scatter interactively →