Fat cell differentiation

Across TCGA cell cohorts, RNA activity of the Fat cell differentiation pathway is significantly associated with the shRNA dependency of multiple genes, with the LARGE_INTESTINE cohort showing a particularly strong set of associations.

The most reproducible pathway-associated genes across cancer lineages are CCND1, ZNF860, and HTR1E, each associated with the pathway in up to 5 cancer types. Since the analysis shows associations rather than directional relationships, both pathway-to-partner and partner-to-pathway views are reported.

Each partner is linked to its corresponding Q-omics profile. The box plot shows the strongest association, CCND1 grouped by Fat cell differentiation-low versus -high activity in LARGE_INTESTINE.

Pathway-associated genes by consensus

Ranked by combined sampling and lineage consensus. X-score (pathway→partner) and Y-score (partner→pathway) are standardized regression coefficients; both directions are reported because the association is undirected. The reported p-values are derived from the association test.

Lineage	Partner gene	X-score	Y-score	p(X)	p(Y)	Sampling consensus	Lineage consensus
LARGE_INTESTINE	CCND1 →	-0.470	-0.149	<.001	<.001	3	5
STOMACH	ZNF860 →	-0.221	-0.208	.007	.003	3	5
BLOOD_Myeloma	HTR1E →	-0.291	-0.138	.002	.002	3	4
LIVER	GTF2IRD2B →	-0.276	-0.220	.003	.008	3	4
LARGE_INTESTINE	COL1A1 →	+0.102	+0.178	.004	.004	3	4
STOMACH	ZFP64 →	-0.247	-0.144	.002	.002	3	4

Each partner links to its Q-omics profile. Showing the 6 strongest associations by consensus.

CCND1 by Fat cell differentiation activity — LARGE_INTESTINE

Explore this box plot interactively →