Fat cell differentiation

Across TCGA cell cohorts, RNA activity of the Fat cell differentiation pathway is significantly associated with the RNA expression of multiple genes, with the OESOPHAGUS cohort showing a particularly strong set of associations.

The most reproducible pathway-associated genes across cancer lineages are OGG1, E2F2, and CENPM, each associated with the pathway in up to 6 cancer types. Since the analysis shows associations rather than directional relationships, both pathway-to-partner and partner-to-pathway views are reported.

Each partner is linked to its corresponding Q-omics profile. The scatter plot shows the strongest association, Fat cell differentiation activity versus OGG1 in OESOPHAGUS (Pearson r = -0.64).

Pathway-associated genes by consensus

Ranked by combined sampling and lineage consensus. X-score (pathway→partner) and Y-score (partner→pathway) are standardized regression coefficients; both directions are reported because the association is undirected. The reported p-values are derived from the association test.

Lineage	Partner gene	X-score	Y-score	p(X)	p(Y)	Sampling consensus	Lineage consensus
OESOPHAGUS	OGG1 →	-0.626	-0.928	.001	.005	3	6
UPPER_AERODIGESTIVE_TRACT	E2F2 →	-0.681	-1.230	.009	.008	3	5
BLOOD_Lymphoma	CENPM →	-1.597	-0.930	<.001	.002	3	5
OESOPHAGUS	NIPA2 →	-0.669	-1.344	.001	.001	3	5
OESOPHAGUS	SFMBT1 →	-1.265	-1.828	<.001	<.001	3	4
KIDNEY	TYRO3 →	-1.438	-1.422	.001	.006	3	4

Each partner links to its Q-omics profile. Showing the 6 strongest associations by consensus.

GO:0045444 vs OGG1 — OESOPHAGUS

Explore this scatter interactively →