Positive regulation of MHC class II biosynthetic process

Across TCGA cell cohorts, RNA activity of the Positive regulation of MHC class II biosynthetic process pathway is significantly associated with the RNA expression of multiple genes, with the UPPER_AERODIGESTIVE_TRACT cohort showing a particularly strong set of associations.

The most reproducible pathway-associated genes across cancer lineages are RFX5, RPS6KA4, and AHNAK, each associated with the pathway in up to 15 cancer types. Since the analysis shows associations rather than directional relationships, both pathway-to-partner and partner-to-pathway views are reported.

Each partner is linked to its corresponding Q-omics profile. The scatter plot shows the strongest association, Positive regulation of MHC class II biosynthetic process activity versus RFX5 in UPPER_AERODIGESTIVE_TRACT (Pearson r = 0.48).

Pathway-associated genes by consensus

Ranked by combined sampling and lineage consensus. X-score (pathway→partner) and Y-score (partner→pathway) are standardized regression coefficients; both directions are reported because the association is undirected. The reported p-values are derived from the association test.

Lineage	Partner gene	X-score	Y-score	p(X)	p(Y)	Sampling consensus	Lineage consensus
UPPER_AERODIGESTIVE_TRACT	RFX5 →	+1.244	+0.097	<.001	.001	3	15
CNS	RPS6KA4 →	-1.371	-0.092	<.001	<.001	3	12
LUNG_SCLC	AHNAK →	-2.594	-0.140	<.001	<.001	3	11
BONE	LASP1 →	-1.126	-0.132	.003	.002	3	11
BONE	PLEC →	-1.773	-0.126	<.001	.001	3	10
LUNG_NSCLC_LUSC	F3 →	-4.051	-0.118	.002	.001	2	11

Each partner links to its Q-omics profile. Showing the 6 strongest associations by consensus.

GO:0045348 vs RFX5 — UPPER_AERODIGESTIVE_TRACT

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