Positive regulation of MHC class I biosynthetic process

Across TCGA patient cohorts, RNA activity of the Positive regulation of MHC class I biosynthetic process pathway is significantly associated with the protein abundance of multiple proteins, with the COAD cohort showing a particularly strong set of associations.

The most reproducible pathway-associated proteins across cancer lineages are CASP1, GBP4, and APOL3, each associated with the pathway in up to 10 cancer types. Since the analysis shows associations rather than directional relationships, both pathway-to-partner and partner-to-pathway views are reported.

Each partner is linked to its corresponding Q-omics profile. The scatter plot shows the strongest association, Positive regulation of MHC class I biosynthetic process activity versus CASP1 in COAD (Pearson r = 0.37).

Pathway-associated proteins by consensus

Ranked by combined sampling and lineage consensus. X-score (pathway→partner) and Y-score (partner→pathway) are standardized regression coefficients; both directions are reported because the association is undirected. The reported p-values are derived from the association test.

Lineage	Partner protein	X-score	Y-score	p(X)	p(Y)	Sampling consensus	Lineage consensus
COAD	CASP1 →	+0.609	+0.060	<.001	.001	3	10
HNSC	GBP4 →	+0.764	+0.165	<.001	<.001	3	10
HNSC	APOL3 →	+0.618	+0.133	<.001	<.001	3	10
BRCA	PSMB10 →	+0.501	+0.110	<.001	<.001	3	10
LSCC	CD74 →	+0.712	+0.192	<.001	<.001	3	9
HNSC	GBP1 →	+0.760	+0.127	<.001	<.001	3	9

Each partner links to its Q-omics profile. Showing the 6 strongest associations by consensus.

GO:0045345 vs CASP1 — COAD

Explore this scatter interactively →