Positive regulation of MHC class I biosynthetic process

Across TCGA cell cohorts, RNA activity of the Positive regulation of MHC class I biosynthetic process pathway is significantly associated with the shRNA dependency of multiple genes, with the KIDNEY cohort showing a particularly strong set of associations.

The most reproducible pathway-associated genes across cancer lineages are NLRP12, CIITA, and HSPH1, each associated with the pathway in up to 6 cancer types. Since the analysis shows associations rather than directional relationships, both pathway-to-partner and partner-to-pathway views are reported.

Each partner is linked to its corresponding Q-omics profile. The box plot shows the strongest association, NLRP12 grouped by Positive regulation of MHC class I biosynthetic process-low versus -high activity in KIDNEY.

Pathway-associated genes by consensus

Ranked by combined sampling and lineage consensus. X-score (pathway→partner) and Y-score (partner→pathway) are standardized regression coefficients; both directions are reported because the association is undirected. The reported p-values are derived from the association test.

Lineage	Partner gene	X-score	Y-score	p(X)	p(Y)	Sampling consensus	Lineage consensus
KIDNEY	NLRP12 →	-0.301	-1.425	<.001	<.001	3	6
SKIN	CIITA →	-0.271	-1.206	<.001	<.001	3	6
SOFT_TISSUE	HSPH1 →	-0.387	-1.403	<.001	.004	3	6
BONE	CHST1 →	-0.288	-1.117	.001	.009	3	5
SKIN	SLC10A3 →	-0.223	-1.194	.003	.001	3	5
CNS	IFNL1 →	-0.272	-1.742	<.001	<.001	3	4

Each partner links to its Q-omics profile. Showing the 6 strongest associations by consensus.

NLRP12 by Positive regulation of MHC class I biosynthetic process activity — KIDNEY

Explore this box plot interactively →