Farnesyl diphosphate metabolic process

Across TCGA patient cohorts, RNA activity of the Farnesyl diphosphate metabolic process pathway is significantly associated with the protein abundance of multiple proteins, with the COAD cohort showing a particularly strong set of associations.

The most reproducible pathway-associated proteins across cancer lineages are GGPS1, BPNT1, and BROX, each associated with the pathway in up to 8 cancer types. Since the analysis shows associations rather than directional relationships, both pathway-to-partner and partner-to-pathway views are reported.

Each partner is linked to its corresponding Q-omics profile. The scatter plot shows the strongest association, Farnesyl diphosphate metabolic process activity versus GGPS1 in COAD (Pearson r = 0.20).

Pathway-associated proteins by consensus

Ranked by combined sampling and lineage consensus. X-score (pathway→partner) and Y-score (partner→pathway) are standardized regression coefficients; both directions are reported because the association is undirected. The reported p-values are derived from the association test.

Lineage	Partner protein	X-score	Y-score	p(X)	p(Y)	Sampling consensus	Lineage consensus
COAD	GGPS1 →	+0.414	+0.064	<.001	<.001	3	8
UCEC	BPNT1 →	+0.401	+0.116	.002	<.001	3	6
LUAD	BROX →	+0.375	+0.067	<.001	<.001	3	5
LSCC	FDPS →	+0.278	+0.052	.009	<.001	3	5
GBM	PLGRKT →	+0.446	+0.056	<.001	<.001	3	5
BRCA	SEC16A →	+0.262	+0.051	<.001	.002	2	5

Each partner links to its Q-omics profile. Showing the 6 strongest associations by consensus.

GO:0045338 vs GGPS1 — COAD

Explore this scatter interactively →