Farnesyl diphosphate metabolic process

Across TCGA patient cohorts, RNA activity of the Farnesyl diphosphate metabolic process pathway is significantly associated with the RNA expression of multiple genes, with the BRCA cohort showing a particularly strong set of associations.

The most reproducible pathway-associated genes across cancer lineages are HMGCS1, FDFT1, and SQLE, each associated with the pathway in up to 8 cancer types. Since the analysis shows associations rather than directional relationships, both pathway-to-partner and partner-to-pathway views are reported.

Each partner is linked to its corresponding Q-omics profile. The scatter plot shows the strongest association, Farnesyl diphosphate metabolic process activity versus HMGCS1 in BRCA (Pearson r = 0.32).

Pathway-associated genes by consensus

Ranked by combined sampling and lineage consensus. X-score (pathway→partner) and Y-score (partner→pathway) are standardized regression coefficients; both directions are reported because the association is undirected. The reported p-values are derived from the association test.

Lineage	Partner gene	X-score	Y-score	p(X)	p(Y)	Sampling consensus	Lineage consensus
BRCA	HMGCS1 →	+0.982	+0.253	<.001	<.001	3	8
COAD	FDFT1 →	+0.700	+0.225	<.001	<.001	3	7
LUAD	SQLE →	+0.981	+0.218	<.001	<.001	3	7
BRCA	IDI1 →	+0.894	+0.174	<.001	<.001	3	6
COAD	FDPS →	+0.662	+0.223	<.001	<.001	3	6
BRCA	MSMO1 →	+0.872	+0.160	.001	.001	3	6

Each partner links to its Q-omics profile. Showing the 6 strongest associations by consensus.

GO:0045338 vs HMGCS1 — BRCA

Explore this scatter interactively →