Farnesyl diphosphate metabolic process

Across TCGA cell cohorts, RNA activity of the Farnesyl diphosphate metabolic process pathway is significantly associated with the RNA expression of multiple genes, with the LUNG_NSCLC_LUAD cohort showing a particularly strong set of associations.

The most reproducible pathway-associated genes across cancer lineages are CYBC1, CD2AP, and KBTBD4, each associated with the pathway in up to 3 cancer types. Since the analysis shows associations rather than directional relationships, both pathway-to-partner and partner-to-pathway views are reported.

Each partner is linked to its corresponding Q-omics profile. The box plot shows the strongest association, CYBC1 grouped by Farnesyl diphosphate metabolic process-low versus -high activity in LUNG_NSCLC_LUAD.

Pathway-associated genes by consensus

Ranked by combined sampling and lineage consensus. X-score (pathway→partner) and Y-score (partner→pathway) are standardized regression coefficients; both directions are reported because the association is undirected. The reported p-values are derived from the association test.

Lineage	Partner gene	X-score	Y-score	p(X)	p(Y)	Sampling consensus	Lineage consensus
LUNG_NSCLC_LUAD	CYBC1 →	-0.474	-0.556	.002	.001	3	3
STOMACH	CD2AP →	+1.139	+0.370	.003	<.001	3	3
PANCREAS	KBTBD4 →	-0.597	-0.955	.003	.005	3	3
BLOOD_Leukemia	PEX14 →	-0.716	-0.915	<.001	.007	3	3
LARGE_INTESTINE	INTS11 →	-0.404	-0.494	.005	.004	3	3
URINARY_TRACT	COA5 →	-0.723	-0.401	.007	.005	3	3

Each partner links to its Q-omics profile. Showing the 6 strongest associations by consensus.

CYBC1 by Farnesyl diphosphate metabolic process activity — LUNG_NSCLC_LUAD

Explore this box plot interactively →