Phospholipid translocation

Across TCGA cell cohorts, RNA activity of the Phospholipid translocation pathway is significantly associated with the RNA expression of multiple genes, with the OVARY cohort showing a particularly strong set of associations.

The most reproducible pathway-associated genes across cancer lineages are C2orf42, FAM81A, and ZNF655, each associated with the pathway in up to 5 cancer types. Since the analysis shows associations rather than directional relationships, both pathway-to-partner and partner-to-pathway views are reported.

Each partner is linked to its corresponding Q-omics profile. The box plot shows the strongest association, C2orf42 grouped by Phospholipid translocation-low versus -high activity in OVARY.

Pathway-associated genes by consensus

Ranked by combined sampling and lineage consensus. X-score (pathway→partner) and Y-score (partner→pathway) are standardized regression coefficients; both directions are reported because the association is undirected. The reported p-values are derived from the association test.

Lineage	Partner gene	X-score	Y-score	p(X)	p(Y)	Sampling consensus	Lineage consensus
OVARY	C2orf42 →	-0.436	-0.848	<.001	.001	3	5
CNS	FAM81A →	+1.313	+1.134	.001	.001	3	5
CNS	ZNF655 →	-0.577	-0.827	.004	.005	3	5
OESOPHAGUS	IMPA2 →	+0.972	+0.894	.002	.002	3	5
OVARY	SOCS5 →	-0.435	-0.715	.002	.008	3	5
CNS	ITGAV →	-1.320	-1.247	<.001	<.001	3	4

Each partner links to its Q-omics profile. Showing the 6 strongest associations by consensus.

C2orf42 by Phospholipid translocation activity — OVARY

Explore this box plot interactively →