Phospholipid translocation

Across TCGA cell cohorts, RNA activity of the Phospholipid translocation pathway is significantly associated with the shRNA dependency of multiple genes, with the OVARY cohort showing a particularly strong set of associations.

The most reproducible pathway-associated genes across cancer lineages are CBR1, ATP6V0A4, and AEBP2, each associated with the pathway in up to 4 cancer types. Since the analysis shows associations rather than directional relationships, both pathway-to-partner and partner-to-pathway views are reported.

Each partner is linked to its corresponding Q-omics profile. The box plot shows the strongest association, CBR1 grouped by Phospholipid translocation-low versus -high activity in OVARY.

Pathway-associated genes by consensus

Ranked by combined sampling and lineage consensus. X-score (pathway→partner) and Y-score (partner→pathway) are standardized regression coefficients; both directions are reported because the association is undirected. The reported p-values are derived from the association test.

Lineage	Partner gene	X-score	Y-score	p(X)	p(Y)	Sampling consensus	Lineage consensus
OVARY	CBR1 →	-0.137	-0.128	.004	.004	3	4
BLOOD_Lymphoma	ATP6V0A4 →	-0.250	-0.207	.005	<.001	3	3
BLOOD_Lymphoma	AEBP2 →	+0.316	+0.218	.006	.001	3	3
BLOOD_Myeloma	SP1 →	+0.202	+0.242	.001	.007	2	4
SOFT_TISSUE	ANGEL2 →	+0.357	+0.282	.002	.002	3	3
LUNG_SCLC	HNRNPUL2 →	+0.473	+0.152	.003	.002	3	3

Each partner links to its Q-omics profile. Showing the 6 strongest associations by consensus.

CBR1 by Phospholipid translocation activity — OVARY

Explore this box plot interactively →