Phospholipid translocation

Across TCGA cell cohorts, RNA activity of the Phospholipid translocation pathway is significantly associated with the RNA expression of multiple genes, with the SOFT_TISSUE cohort showing a particularly strong set of associations.

The most reproducible pathway-associated genes across cancer lineages are TMBIM1, JUP, and LIN52, each associated with the pathway in up to 4 cancer types. Since the analysis shows associations rather than directional relationships, both pathway-to-partner and partner-to-pathway views are reported.

Each partner is linked to its corresponding Q-omics profile. The scatter plot shows the strongest association, Phospholipid translocation activity versus TMBIM1 in SOFT_TISSUE (Pearson r = -0.75).

Pathway-associated genes by consensus

Ranked by combined sampling and lineage consensus. X-score (pathway→partner) and Y-score (partner→pathway) are standardized regression coefficients; both directions are reported because the association is undirected. The reported p-values are derived from the association test.

Lineage	Partner gene	X-score	Y-score	p(X)	p(Y)	Sampling consensus	Lineage consensus
SOFT_TISSUE	TMBIM1 →	-1.165	-0.308	.004	.007	3	4
UPPER_AERODIGESTIVE_TRACT	JUP →	-1.197	-0.160	<.001	.002	3	4
SOFT_TISSUE	LIN52 →	+0.771	+0.196	.002	.002	3	3
SOFT_TISSUE	MRPL33 →	-1.228	-0.216	<.001	.001	3	3
SOFT_TISSUE	CDC7 →	+1.155	+0.278	.004	.006	3	3
LARGE_INTESTINE	DNAJC9 →	+0.568	+0.739	.008	.003	3	3

Each partner links to its Q-omics profile. Showing the 6 strongest associations by consensus.

GO:0045332 vs TMBIM1 — SOFT_TISSUE

Explore this scatter interactively →