Late endosome to vacuole transport

Across TCGA patient cohorts, RNA activity of the Late endosome to vacuole transport pathway is significantly associated with the protein abundance of multiple proteins, with the BRCA cohort showing a particularly strong set of associations.

The most reproducible pathway-associated proteins across cancer lineages are RPS19, RPS2, and RPS5, each associated with the pathway in up to 6 cancer types. Since the analysis shows associations rather than directional relationships, both pathway-to-partner and partner-to-pathway views are reported.

Each partner is linked to its corresponding Q-omics profile. The scatter plot shows the strongest association, Late endosome to vacuole transport activity versus RPS19 in BRCA (Pearson r = -0.19).

Pathway-associated proteins by consensus

Ranked by combined sampling and lineage consensus. X-score (pathway→partner) and Y-score (partner→pathway) are standardized regression coefficients; both directions are reported because the association is undirected. The reported p-values are derived from the association test.

Lineage	Partner protein	X-score	Y-score	p(X)	p(Y)	Sampling consensus	Lineage consensus
BRCA	RPS19 →	-0.210	-0.035	.009	.004	3	6
PDAC	RPS2 →	-0.266	-0.040	<.001	<.001	3	6
GBM	RPS5 →	-0.218	-0.051	.001	<.001	3	6
GBM	RPL11 →	-0.217	-0.040	.001	.003	3	6
GBM	RPL10A →	-0.179	-0.045	.008	.001	3	5
GBM	RPLP0 →	-0.332	-0.053	<.001	<.001	3	5

Each partner links to its Q-omics profile. Showing the 6 strongest associations by consensus.

GO:0045324 vs RPS19 — BRCA

Explore this scatter interactively →