Late endosome to vacuole transport

Across TCGA cell cohorts, RNA activity of the Late endosome to vacuole transport pathway is significantly associated with the RNA expression of multiple genes, with the URINARY_TRACT cohort showing a particularly strong set of associations.

The most reproducible pathway-associated genes across cancer lineages are CTDP1, IL4R, and TGFA, each associated with the pathway in up to 5 cancer types. Since the analysis shows associations rather than directional relationships, both pathway-to-partner and partner-to-pathway views are reported.

Each partner is linked to its corresponding Q-omics profile. The box plot shows the strongest association, CTDP1 grouped by Late endosome to vacuole transport-low versus -high activity in URINARY_TRACT.

Pathway-associated genes by consensus

Ranked by combined sampling and lineage consensus. X-score (pathway→partner) and Y-score (partner→pathway) are standardized regression coefficients; both directions are reported because the association is undirected. The reported p-values are derived from the association test.

Lineage	Partner gene	X-score	Y-score	p(X)	p(Y)	Sampling consensus	Lineage consensus
URINARY_TRACT	CTDP1 →	-0.661	-0.306	.001	<.001	3	5
PANCREAS	IL4R →	+1.670	+0.306	<.001	<.001	3	5
PANCREAS	TGFA →	+1.932	+0.227	.008	.009	3	5
PANCREAS	PTAFR →	+2.355	+0.293	.001	.003	3	5
LUNG_NSCLC_LUAD	TSPAN1 →	+2.645	+0.232	.003	.006	3	5
LUNG_NSCLC_LUAD	KIAA1217 →	+1.174	+0.237	.005	.008	3	5

Each partner links to its Q-omics profile. Showing the 6 strongest associations by consensus.

CTDP1 by Late endosome to vacuole transport activity — URINARY_TRACT

Explore this box plot interactively →