Late endosome to vacuole transport

Across TCGA cell cohorts, RNA activity of the Late endosome to vacuole transport pathway is significantly associated with the protein abundance of multiple proteins, with the URINARY_TRACT cohort showing a particularly strong set of associations.

The most reproducible pathway-associated proteins across cancer lineages are VTA1, PSMD7, and AIP, each associated with the pathway in up to 17 cancer types. Since the analysis shows associations rather than directional relationships, both pathway-to-partner and partner-to-pathway views are reported.

Each partner is linked to its corresponding Q-omics profile. The scatter plot shows the strongest association, Late endosome to vacuole transport activity versus VTA1 in URINARY_TRACT (Pearson r = 0.80).

Pathway-associated proteins by consensus

Ranked by combined sampling and lineage consensus. X-score (pathway→partner) and Y-score (partner→pathway) are standardized regression coefficients; both directions are reported because the association is undirected. The reported p-values are derived from the association test.

Lineage	Partner protein	X-score	Y-score	p(X)	p(Y)	Sampling consensus	Lineage consensus
URINARY_TRACT	VTA1 →	+2.046	+1.749	<.001	<.001	3	17
URINARY_TRACT	PSMD7 →	+1.420	+1.757	<.001	<.001	3	17
URINARY_TRACT	AIP →	+2.008	+1.546	<.001	<.001	3	16
URINARY_TRACT	PSMD9 →	+2.418	+1.711	.001	<.001	3	16
URINARY_TRACT	DENR →	+1.643	+1.714	<.001	<.001	3	16
URINARY_TRACT	PSMC6 →	+1.087	+1.573	<.001	<.001	3	16

Each partner links to its Q-omics profile. Showing the 6 strongest associations by consensus.

GO:0045324 vs VTA1 — URINARY_TRACT

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