"mRNA cis splicing, via spliceosome"

Across TCGA patient cohorts, RNA activity of the "mRNA cis splicing, via spliceosome" pathway is significantly associated with the protein abundance of multiple proteins, with the PDAC cohort showing a particularly strong set of associations.

The most reproducible pathway-associated proteins across cancer lineages are AP1G1, GSPT1, and PEAK1_S826, each associated with the pathway in up to 6 cancer types. Since the analysis shows associations rather than directional relationships, both pathway-to-partner and partner-to-pathway views are reported.

Each partner is linked to its corresponding Q-omics profile. The scatter plot shows the strongest association, "mRNA cis splicing, via spliceosome" activity versus AP1G1 in PDAC (Pearson r = -0.35).

Pathway-associated proteins by consensus

Ranked by combined sampling and lineage consensus. X-score (pathway→partner) and Y-score (partner→pathway) are standardized regression coefficients; both directions are reported because the association is undirected. The reported p-values are derived from the association test.

Lineage	Partner protein	X-score	Y-score	p(X)	p(Y)	Sampling consensus	Lineage consensus
PDAC	AP1G1 →	-0.136	-0.034	.002	<.001	3	6
COAD	GSPT1 →	-0.286	-0.050	<.001	<.001	3	5
COAD	PEAK1_S826 →	+0.295	+0.038	.001	.001	3	5
BRCA	FGL2 →	+0.334	+0.022	.002	.008	3	5
LSCC	ZC3HAV1_S101 →	-1.045	-0.041	.002	.002	3	5
LSCC	PIEZO1 →	-0.405	-0.064	<.001	<.001	3	5

Each partner links to its Q-omics profile. Showing the 6 strongest associations by consensus.

GO:0045292 vs AP1G1 — PDAC

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