"mRNA cis splicing, via spliceosome"

Across TCGA patient cohorts, RNA activity of the "mRNA cis splicing, via spliceosome" pathway is significantly associated with the protein abundance of multiple proteins, with the OV cohort showing a particularly strong set of associations.

The most reproducible pathway-associated proteins across cancer lineages are SRRM2_S1083, RBBP6_S772, and SRRM2_S1916, each associated with the pathway in up to 9 cancer types. Since the analysis shows associations rather than directional relationships, both pathway-to-partner and partner-to-pathway views are reported.

Each partner is linked to its corresponding Q-omics profile. The scatter plot shows the strongest association, "mRNA cis splicing, via spliceosome" activity versus SRRM2_S1083 in OV (Pearson r = 0.33).

Pathway-associated proteins by consensus

Ranked by combined sampling and lineage consensus. X-score (pathway→partner) and Y-score (partner→pathway) are standardized regression coefficients; both directions are reported because the association is undirected. The reported p-values are derived from the association test.

Lineage	Partner protein	X-score	Y-score	p(X)	p(Y)	Sampling consensus	Lineage consensus
OV	SRRM2_S1083 →	+0.722	+0.316	.001	.001	2	9
BRCA	RBBP6_S772 →	+0.713	+0.306	<.001	<.001	3	8
CCRCC	SRRM2_S1916 →	+1.542	+0.378	<.001	<.001	3	7
BRCA	ANP32B_T15 →	+0.642	+0.198	<.001	.001	2	8
HNSC	RSF1_S1282 →	+0.892	+0.229	<.001	<.001	3	7
GBM	SNRPD2 →	+0.342	+0.386	<.001	<.001	3	7

Each partner links to its Q-omics profile. Showing the 6 strongest associations by consensus.

GO:0045292 vs SRRM2_S1083 — OV

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