Cell-cell junction maintenance

Across TCGA patient cohorts, RNA activity of the Cell-cell junction maintenance pathway is significantly associated with the RNA expression of multiple genes, with the UCEC cohort showing a particularly strong set of associations.

The most reproducible pathway-associated genes across cancer lineages are ZNF782, CDS1, and TJP1, each associated with the pathway in up to 6 cancer types. Since the analysis shows associations rather than directional relationships, both pathway-to-partner and partner-to-pathway views are reported.

Each partner is linked to its corresponding Q-omics profile. The scatter plot shows the strongest association, Cell-cell junction maintenance activity versus ZNF782 in UCEC (Pearson r = 0.34).

Pathway-associated genes by consensus

Ranked by combined sampling and lineage consensus. X-score (pathway→partner) and Y-score (partner→pathway) are standardized regression coefficients; both directions are reported because the association is undirected. The reported p-values are derived from the association test.

Lineage	Partner gene	X-score	Y-score	p(X)	p(Y)	Sampling consensus	Lineage consensus
UCEC	ZNF782 →	+0.396	+0.344	<.001	.004	3	6
HNSC	CDS1 →	+0.840	+0.380	<.001	<.001	3	6
GBM	TJP1 →	+0.512	+0.292	<.001	.001	3	5
HNSC	BSPRY →	+0.895	+0.275	.002	<.001	3	5
LSCC	HAPLN3 →	-0.694	-0.504	<.001	<.001	3	5
LUAD	PLEKHA7 →	+0.491	+0.554	.003	.001	3	5

Each partner links to its Q-omics profile. Showing the 6 strongest associations by consensus.

GO:0045217 vs ZNF782 — UCEC

Explore this scatter interactively →